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doi:10.1038/s41423-024-01208-z

BMJ 2023;382:p2019.Article 72

indicates that co-delivering oligonucleotides targeting the 5 or 3 untranslated regions of Frataxin can extend the mRNA half-life, leading to increased steady-state levels of Frataxin mRNA and protein, suggesting a novel approach to upregulating mRNA levels in any transcriptionally downregulated disorder